Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

E Assana; CT Kyngdon; CG Gauci; S Geerts; P Dorny; R De Deken; GA Anderson; AP Zoli; MW Lightowlers

Journal article

Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

E Assana, CT Kyngdon, CG Gauci, S Geerts, P Dorny, R De Deken, GA Anderson, AP Zoli, MW Lightowlers

International Journal for Parasitology | Published : 2010

DOI: 10.1016/j.ijpara.2010.01.006

Abstract

A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3. month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200μg TSOL18 plus 5. mg Quil A and 30. mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12. months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P<0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure tha..

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University of Melbourne Researchers

Charles Gauci Author

Marshall Lightowlers Author

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Research Fellowship

Grants

Awarded by Wellcome Trust

Funding Acknowledgements

Funding is acknowledged from The Wellcome Trust, Animal Health in the Developing World Grant 075818 and the Australian National Health and Medical Research Council grants 350279, 400109 and 628320.